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apalutamide will minimize the extent or impact of triazolam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with medicines which might be CYP3A4 substrates can result in reduced exposure to these remedies.Offering or freely giving estazolam may perhap